It is well known that adequate oxygen is essential for human survival, and oxygen plays an irreplaceable role in many aspects.

Healing has become a major issue for the global health system. In industrialized societies, about 1-1.5% of the population will have a refractory wound once in their lifetime. In addition, wound management is very expensive; Wound management in Europe accounts for about 2-4% of the overall medical budget. These Numbers are likely to rise as the elderly and diabetic population increase.

Wound healing requires the restoration of large/microcirculation, of which one of the most important, or at least one of the most immediate needs, is oxygen, which is important for the reconstruction of new blood vessels and connective tissue and for building infection defenses. An adequate supply of oxygen is therefore essential for the healing of difficult wounds. This has been demonstrated in wounds and diabetic feet associated with peripheral arterial occlusive disease (PAOD). In addition, there is growing evidence that hypoxia/hypoxia plays an important role in almost all types of refractory wounds.

Oxygen Therapy is the general term that encompasses both hyperbaric Oxygen Therapy (HBOT) and Topical Oxygen Therapy (TOT). HBOT is well known and has been used in the field of wound treatment. On the other hand, new wound treatments based on TOT have been developed in recent years. However, toT-related techniques are relatively new and there are only a few clinical studies. In the future, the relationship between TOT and HBOT should also be considered.