We know that nitrous oxide has an anesthetic effect at room temperature and can be used as an anesthetic gas. In fact, at room temperature there is another gas also anaesthetic effect, that is, xenon. Xenon has medical as well as manufacturing USES, the chief of which is narcotics.

It was only in the last century that the anesthetic effects of xenon were discovered. Relevant materials show:

In 1946, Laurence et al. identified the analgesic effects of xenon

In 1950, Cullen and Gross first used xenon in surgery

After years of clinical application, the anesthetic effect of xenon and some of its advantages have been proved. Xenon has no occupational and environmental hazards, strong anesthetic efficacy, certain analgesic effect, need very few auxiliary drugs, especially fast induction of anesthesia, quick awakening, not easy to be affected by biological transformation, is now known to have the least impact on cardiovascular anaesthetic. Animal experiments showed little change in hemodynamics and a slight 

decrease in heart rate after xenon anesthesia. Xenon gas had no obvious effect on heart rate, atrioventricular conduction velocity, coronary blood flow, myocardial oxygen consumption and oxygen uptake. That xenon is therefore an ideal anesthetic. Xenon can be used for anesthesia in a variety of operations, such as general surgery, gynecology, orthopedic surgery and orthopedic surgery.

In addition, xenon has many pharmacodynamic and pharmacokinetic properties, making it suitable for use in certain clinical Settings, such as cardiopulmonary bypass surgery. These anesthetic and analgesic effects of xenon have important organ maintenance effects, especially on the brain and heart. The incidence of cerebral and cardiac blockages decreased after xenon anesthesia. Although xenon is expensive, xenon 

interacts with a variety of molecular targets to benefit patients with acute 

cardiovascular or neurological risk, or both.

So how does xenon play an anaesthetic role? Studies show that xenon performs anaesthetic effects through "multiple pathways," which have not yet been fully determined, except in clinical practice.

The "anesthetic pathways" of xenon are mainly as follows:

1) the effect is produced by suppressing the central nervous system nmDA(aspartic acid) receptor and acetylcholine receptor.

2) it interacts with the membrane protein and membrane structure, and inhibits the Ca2+ pump on the plasma membrane, resulting in the increase of Ca2+ and the modification of its excitability.

This effect may be mediated by nmDA receptors.